The advance of any cancer is determined not only by the molecular characteristics of the tumor itself but also by its interaction with the cells that surround it. Yet understanding how exactly these interactions in the tumor microenvironment influence the...
Craig M. Crews, the John C. Malone Professor of Molecular, Cellular, and Developmental Biology in Yale’s Faculty of Arts and Sciences and a pioneer in the pharmaceutical field of targeted protein degradation, has been named the winner of the 2024 Kimberly...
The explosive rise in tick-borne diseases in many parts of the United States over the last five decades represents a major public health threat that demands innovative solutions, warns a group of Yale scientists. In a review article, they outline why the...
Yale researchers have identified a drug target that may alleviate joint degeneration associated with osteoarthritis, a debilitating condition that afflicts as many as 30 million people in the United States alone, they report Jan. 3 in the journal Nature....
For centuries, a prevailing theory in philosophy has asserted that at birth the human mind is a blank slate. More recently the same notion has also held sway in the field of neurobiology, where it is commonly held that neural connections are slowly...
The quest for personalized medicine, a medical approach in which practitioners use a patient’s unique genetic profile to tailor individual treatment, has emerged as a critical goal in the health care sector. But a new Yale-led study shows that the...
Ribonucleic acids (RNAs) are the ultimate cellular insiders. They perform several critical jobs, such as ferrying genetic instructions from a living organism’s DNA to its protein-making machinery (a process key to cellular processes) and controlling which...
Every system in a living organism depends upon a finite supply of energy in order to function. In humans, no organ is more energy-intensive than the brain, which consumes about 20% of the body’s metabolic energy.
But how is energy distributed in the...
It’s well known that plants have a fine-tuned ability to sense changes in the season by how much daylight they’re exposed to, yet scientists observed more than a century ago that plants sometimes grow during one season and flower in another. Most research...
An overly robust immune response to usually harmless germs has been linked to colitis, a potentially severe inflammation of the colon that afflicts millions of people worldwide. A new Yale-led study not only reveals that the presence of one class of fatty...