Cancer immunotherapy has revolutionized treatment of many forms of cancer by unleashing the immune system response against tumors. Immunotherapies that block checkpoint receptors like PD-1, proteins that limit the capacity of T cells to attack tumors,...
A study of more than 22,000 people with multiple sclerosis (MS) has for the first time identified a genetic variant associated with faster progression of the disease, an accumulation of disability that can rob patients of their mobility and independence...
Simply the smell of seafood can make those with an allergy to it violently ill — and therefore more likely to avoid it. The same avoidance behavior is exhibited by people who develop food poisoning after eating a certain meal.
Scientists have long known...
Vaccines that spur the creation of antibodies designed to attack specific spike proteins of the SARS-CoV-2 virus have been the principal defense against COVID-19. However, Yale researchers have found that local cells that line airways of the respiratory...
The role played by mutations in the LRRK2 gene in promoting Parkinson’s disease has long intrigued scientists, and even led to an experimental drug that inhibits the over-active protein. Yet exactly how LRRK2 triggers this devastating neurodegenerative...
All humans have a diverse set of blood stem cell types which dictate the composition and function of our blood and immune cells and ultimately help govern overall health. Older people tend to lose this diversity of blood stem cells, which can make them...
In a promising form of immunotherapy known as CAR T-cell (chimeric antigen receptor) therapy, the patient’s T cells are engineered to better recognize and attack antigens on the surface of cancer cells. In treatments currently approved for use in battling...
Healthy human skin is a mosaic-like collection of both normal and mutation-bearing cells. As people age, a growing number of these cells accumulate more and more mutations including those that can cause cancer. Eventually these mutant cells, which are...
Two distinct neurodevelopmental abnormalities that arise just weeks after the start of brain development have been associated with the emergence of autism spectrum disorder, according to a new Yale-led study in which researchers developed brain organoids...
Yale researchers have created a functional “humanized” liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of...