Each month during women’s reproductive years, the uterus sheds and regenerates the tissue lining its walls in preparation for a pregnancy or the next cycle. The process behind this age-old and essential part of human reproduction is not well understood....
What makes healthy cells change and become dysfunctional to the point of causing disease? In addition to a disruption in genes that regulate cells, there is another factor in cell misbehavior that involves metabolism, say Yale researchers.
The research...
Listeria bacteria in food, water, or soil can cause food poisoning and even life-threatening infections in vulnerable people. In a study, Yale investigators have described how the pathogen manipulates the immune system to promote its own survival.
The...
Treatments for Parkinson’s disease have most recently focused on increasing dopamine, a chemical messenger in the brain that affects reward-based behaviors and motivation, as well as movement. A new study by Yale researchers challenges long-held...
To overcome an infection, the immune system has to both kill the invading virus or bacterium, and tolerate the inflammation triggered by the infection. In a new study, Yale researchers have figured out a key component of the second infection-fighting...
When a 9-year-old girl with anemia, breathing problems, and recurrent infections sought help for her mysterious ailments, Yale researchers and their collaborators at the National Institutes of Health sequenced her genes to pinpoint a cause. What they...
The best hope for people with an inherited form of kidney disease that causes kidney failure is dialysis or a kidney transplant. But a study led by Yale researchers reveals a potential strategy for developing new drug therapies for these patients.
Senior...
Bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response, according to a new Yale study. The researchers also found that the autoimmune reaction can be suppressed with an antibiotic or vaccine...
Patients with irritable bowel syndrome who follow individualized diets based on food sensitivity testing experience fewer symptoms, say Yale researchers. Their study is among the first to provide scientific evidence for this medication- free approach to a...
An international Yale-led research team has shown that a risk profile based on 52 genes accurately predicts survival for patients with a severe lung disease. If confirmed in further studies, the finding could transform the way patients are treated for the...