Scientists have long searched for “driver” genes that fuel the progression of cancer, but existing technology has had a hard time separating mutations that are true drivers from others that are simply “passengers,” not directly involved in spread of...
Immunotherapy has revolutionized the treatment of cancer in the last decade, yet many tumors do not respond to these new therapies. A new genome-wide screen of 20,000 human genes in T cells have turned up several new candidates to unleash the immune...
As cells age, they accumulate signs of DNA damage. Breaks in both strands of the DNA molecule are especially toxic and have been linked to increased genomic instability and cancer risk with age. A new Yale study of yeast quantifies how the age of a cell...
Even in patients who receive long-term anti-retroviral treatment, cells containing HIV remain in the cerebrospinal fluid of half of those treated for the disease, and those individuals are more likely to experience cognitive deficits than those without...
A prevailing theory in neuroscience holds that people make decisions based on integrated global calculations that occur within the frontal cortex of the brain.
However, Yale researchers have found that three distinct circuits connecting to different...
Of all forms of memory, episodic memory is the most intimate. We recall the sequences of events that happen to us — a marriage, a visit to a foreign country, a personal achievement — in great autobiographical detail. But scientists have disagreed about...
Even after antibiotic treatment, some Lyme disease patients continue to suffer from debilitating arthritis. A new Yale study may explain why.
The tick-borne bacterium Borrelia burgdorferi leaves behind parts of its cell wall in patients’ joints, which...
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 in the journal Nature.
Scientists in...
Sperm start their sprint to the ovum when they detect changes in the environment through a series of calcium channels arranged like racing stripes on their tails. A team of Yale researchers has identified a key molecule that coordinates the opening and...