For centuries, a prevailing theory in philosophy has asserted that at birth the human mind is a blank slate. More recently the same notion has also held sway in the field of neurobiology, where it is commonly held that neural connections are slowly...
Yale researchers have identified a drug target that may alleviate joint degeneration associated with osteoarthritis, a debilitating condition that afflicts as many as 30 million people in the United States alone, they report Jan. 3 in the journal Nature....
Craig M. Crews, the John C. Malone Professor of Molecular, Cellular, and Developmental Biology in Yale’s Faculty of Arts and Sciences and a pioneer in the pharmaceutical field of targeted protein degradation, has been named the winner of the 2024 Kimberly...
The advance of any cancer is determined not only by the molecular characteristics of the tumor itself but also by its interaction with the cells that surround it. Yet understanding how exactly these interactions in the tumor microenvironment influence the...
It is well known that people who have lived through traumatic events like sexual assault, domestic abuse, or violent combat can experience symptoms of post-traumatic stress disorder (PTSD), including terrifying flashbacks, severe anxiety, and...
To carry out all of life’s functions, proteins must be produced from instructions carried by genes within DNA and delivered to the cell’s protein-making machinery by messenger RNA.
However, to generate mature mRNA, intervening sequences called introns...
A Yale-led analysis of the genomes of more than 1 million people has shed light on the underlying biology of cannabis use disorder and its links to psychiatric disorders, abuse of other substances such as tobacco, and possibly even an elevated risk of...
An experimental drug can reduce the toxic changes in tau proteins known to damage neurons in brains with Alzheimer’s disease, researchers from Yale School of Medicine and Johns Hopkins University report.
While much research related to Alzheimer’s disease...
The development of the brain requires an elaborate, tightly organized chain of events that are jumpstarted by neural stem cells, which give rise to increasingly specialized cells that carry out all brain functions. But what molecular events occur during...
When Yale neuroscientist Joy Hirsch used sophisticated imaging tools to track in real time the brain activity of two people engaged in conversation, she discovered an intricate choreography of neural activity in areas of the brain that govern social...