When a 9-year-old girl with anemia, breathing problems, and recurrent infections sought help for her mysterious ailments, Yale researchers and their collaborators at the National Institutes of Health sequenced her genes to pinpoint a cause. What they...
To overcome an infection, the immune system has to both kill the invading virus or bacterium, and tolerate the inflammation triggered by the infection. In a new study, Yale researchers have figured out a key component of the second infection-fighting...
Treatments for Parkinson’s disease have most recently focused on increasing dopamine, a chemical messenger in the brain that affects reward-based behaviors and motivation, as well as movement. A new study by Yale researchers challenges long-held...
Listeria bacteria in food, water, or soil can cause food poisoning and even life-threatening infections in vulnerable people. In a study, Yale investigators have described how the pathogen manipulates the immune system to promote its own survival.
The...
What makes healthy cells change and become dysfunctional to the point of causing disease? In addition to a disruption in genes that regulate cells, there is another factor in cell misbehavior that involves metabolism, say Yale researchers.
The research...
Each month during women’s reproductive years, the uterus sheds and regenerates the tissue lining its walls in preparation for a pregnancy or the next cycle. The process behind this age-old and essential part of human reproduction is not well understood....
What drives the social bond between offspring and caregivers in the first few days of life? A Yale-led team of researchers has found clues in specific neurons in the brains of neonatal mice that are associated with feeding.
The neurons, known as Agrp,...
The best hope for people with an inherited form of kidney disease that causes kidney failure is dialysis or a kidney transplant. But a study led by Yale researchers reveals a potential strategy for developing new drug therapies for these patients.
Senior...
By targeting a protein found in the saliva of mosquitoes that transmit Zika virus, Yale investigators reduced Zika infection in mice. The finding demonstrates how researchers might develop a vaccine against Zika and similar mosquito-borne viruses, the...
Scientists have recently recognized that cells of the same type can behave differently in response to stimulation. In a new study, Yale researchers have shown how these varied responses are due in part to a desynchronized molecular “clock” within cell...