Altering an enzyme pathway: new Yale study

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Yale scientists in the Department of Chemistry and the Department of Molecular Biophysics and Biochemistry have combined state-of-the-art nuclear magnetic resonance and computational techniques to effectively alter an important enzyme pathway and predictably alter enzyme function. The researchers describe the method in a new study in the Proceedings of the National Academy of Sciences. The authors are George Lisi, Kyle East, Victor Batista, and J. Patrick Loria.

“Insight from this work should impact enzyme regulation in general and aid in identification of novel regions that could be exploited to modulate function in complex biological targets,” Loria said.

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Jim Shelton: james.shelton@yale.edu, 203-361-8332