Cellular alchemy caught in action

This video shows how four genetic factors introduced into a blood cell (yellow arrow) that was taken from the bone marrow creates embryonic-like stem cells (in green) with the capacity to become almost any tissue in the body — a process called reprogramming. Scientists are hopeful that understanding reprogramming will lead to advances in cell-based therapies to treat a host of serious diseases.

One of the most critical biological advances in the past decade was the discovery that the introduction of four simple genetic factors can turn a fully mature adult cell back into an embryonic-like state, a process called reprogramming.

Now, Yale School of Medicine researchers have created a video that shows in great detail how this transformation takes place. The Yale team introduced these genetic factors into a blood cell and watched as it formed a colony of pluripotent cells, which are capable of becoming many different types of cells.

The reprogramming process holds the promise of creating cell-based therapy for a host of serious diseases. However it has been a mystery how and when an individual cell decides to make this drastic change.

“These movies show that the process is more complicated than we thought. Now that we can see how it happens, we have an opportunity to getting to know the cells better, and control their behaviors better,” said Shangqin Guo, research scientist at the Yale Stem Cell Center and lead author of the study, published in the journal Stem Cells.

(Image via Shutterstock)

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Media Contact

Bill Hathaway: william.hathaway@yale.edu, 203-432-1322