Yale Stem Cell Researchers Reap State Grants
Yale University researchers received almost $4 million from the state of Connecticut to study ways human embryonic stem cells can be used to treat ailments as diverse as spinal cord injuries, cancer and mental retardation.
Five researchers received grants worth $2.5 million and while seven other researchers received seed grants worth $1.4 million, the Connecticut Department of Public Health announced April 1. The grants by the Connecticut Stem Cell Advisory Committee were made under a 2005 state law which designated $100 million over 10 years to promote stem cell research in Connecticut. Connecticut was the third such state to pass legislation authorizing use of funds to study embryonic stem cells.
Project titles, Yale principal investigators and grant amounts are:
Cellular transplantation of neural progenitors derived from human embryonic stem cells to remyelinate the nonhuman primate spinal cord, Jeffery Kocsis,$500,000.
piggyBac Transposon for Genetic Manipulation and Insertional Mutagenesis in Human Embryonic Stem Cells, Tian Xu, $500,000.
MicroRNA regulation of (Human Embryonic Cell) fates, Jun Lu, $500,000.
Genome-wide screen to identify hESC-specific DNA transcription elements, Richard Sutton, $500,000.
Molecular function of Lin28 in human embryonic stem cells, Yingqun Huang, $500,000.
Derivation and Functional Characterization of Heart Cells from Human Embryonic Stem Cells, Yibing Qyang,$200,000.
The Influence of Aberrant Notch Signaling on Rb Mediated Cell Cycle Regulation in Megakaryopoiesis & Acute Megakaryoblastic Leukemia, Stephanie Massaro, $200,000.
Investigating the role of nuclear RNA quality surveillance in embryonic stem cells, Sandra Wolin, $200,000.
Molecular profiling and cell fate potential of hESC-derived early neural crest precursors, Martín I García-Castro, $200,000.
Neural Stem Cell Responses to Hypoxia, Qi Li, $200,000.
Induction and differentiation of beta cells from human embryonic stem cells, Kevan Herold, $200,000.
Transcriptional control of keratinocyte differentiation in human ES cells, Valerie Horsley, $200,000.