Dr. Lloyd Cantley Named the Long Professor of Medicine

Dr. Lloyd G. Cantley, newly designated as the C.N.H. Long Professor of Medicine, is a noted nephrologist who focuses his research on the mechanisms of renal tubule formation and repair.

By examining epithelial cell adhesion, migration and branching tubulogenesis in response to growth factors such as Hepatocyte Growth Factor and Epidermal Growth Factor, Cantley and colleagues in his laboratory are determining the intracellular signaling events critical for tubule formation during kidney development and following injury. They are focusing on the role of activation of specific MAPK isoforms as well as the PI 3-kinase in the regulation of cell morphogenesis and cell-matrix interactions.

In addition, Cantley is examining the role of adult stem cells in the recovery from acute tubular necrosis, a medical condition that is one of the most common causes of acute renal failure. Cantley and his colleagues have found that stems cells in bone marrow can home to and populate the injured tubule, where they differentiate into tubular epithelial cells. He is presently examining how these cells can be mobilized for therapeutic use in cases of acute renal failure. His aim is to reach a more detailed understanding of the events that promote tubule formation and to augment kidney tubule repair and prevent long-term scarring following renal injury.

At Yale, Cantley is affiliated with the Department of Internal Medicine’s Section of Nephrology and with the School of Medicine’s Biological and Biomedical Sciences Program. He became a full professor at the University two years ago. He serves as the director of fellowship recruitment in internal medicine and is associate director of the Clinical Fellowship Program. His research has been published in the Journal of Biological Chemistry, the Journal of Clinical Investigation and the Proceedings of the National Academy of Science, among other publications.

The Yale physician earned his B.S. at West Virginia Wesleyan College and his M.D. from the West Virginia School of Medicine. He completed his residency at North Carolina Memorial Hospital and his fellowship training in nephrology at Beth Israel Hospital in Boston.

Cantley is an associate editor of the Journal of the American Society of Nephrology.

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