Langerhans Cells Regulate Immune Reactions in the Skin

The langerhans cells are marked in red and another cell type are in green. Wild-type mice are on the bottom and have both the red and green cells. Then transgenic mice are on the top and still have the green cells but the red cells are missing. Researchers at Yale School of Medicine have demonstrated that Langerhans cells in the skin, which had been thought to alert the immune system to pathogens, instead dampen the skin’s reaction to infection and inflammation.