Symposium Celebrates Yale's W.M. Keck Magnetic Resonance Lab

“Frontiers in Magnetic Resonance,” a symposium in celebration of the dedication of the W.M. Keck High Field Magnetic Resonance Laboratory at Yale University, will be held Saturday, May 30, at Sterling Chemistry Laboratory, 25 Prospect St.

Experts in nuclear magnetic resonance – NMR – from throughout the United States and from Germany will speak at the day-long symposium, which begins at 9 a.m. The last symposium speaker from 2:15-3 p.m. will be Yale chemistry professor Kurt Zilm, the lab’s director, who will speak on “Challenges in High Resolution NMR of Solids at High Magnetic Fields,” followed by the dedication and reception 3-4 p.m. Attending the dedication will be Yale President Richard C. Levin and Provost Alison Richard. The public is invited.

“Since 1945, NMR spectroscopy has grown to become one of the most important methods for chemical and structural analysis in chemistry, biology, materials physics and medicine,” Zilm said. “Conceived as a multidisciplinary center, the W.M. Keck High Field Magnetic Resonance Laboratory at Yale is unique in being configured to accommodate NMR research spanning all of these diverse disciplines.”

Construction of the laboratory began in 1994 to house a Tesla magnet, fabricated by Oxford Instruments. The laboratory has been intensely pursuing the advancements in NMR hardware needed to take full advantage of this new class of NMR magnet, Zilm said. For example, the first-ever high resolution spectra of solid samples at such field strengths were obtained in the laboratory in December 1997, nearly a year ahead of schedule. With the improved technology, it has been possible to extend the range of macromolecular structures that can be studied using NMR.

“To achieve this milestone in magnetic resonance, it was necessary to put together a partnership of scientific organizations with interests in pushing forward frontiers in scientific instrumentation,” said Zilm, who added that the laboratory was established with the generous support of the W. M. Keck Foundation, Exxon Research and Engineering Co. and the National Science Foundation.

Morning session

8:30-9 a.m. continental breakfast

9-9:45 a.m.: Professor Christian Griesinger, University of Frankfurt, “Projection Restraints as a Tool for Analysis of Molecular Structure and Dynamics”

9:45-10:30 a.m.: Professor Ann McDermott, Columbia University, “Mechanism of Nuclear Polarization Development in the Photocycling of Reaction Centers”

10:40-11:25 a.m: Professor Jacob Schaefer, Washington University, “Rotational Echo Double Resonance Spectroscopy of Biological and Synthetic Glasses”

11:25 a.m.-12:10 p.m.: Professor John Gore, Yale University, “Human Brain Mapping with NMR”

Afternoon session

1:30-2:15 p.m.: Professor Gaetano Montelione, Rutgers University, “Automated Analysis of Multidimensional Protein NMR Spectra and Structural Genomics”

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